ORCHARD PARK, N.Y. -- San Francisco 49ers running back Christian McCaffrey suffered what is believed to be an injury to the ...

The wife of San Francisco 49ers offensive tackle Trent Williams announced their son, Trenton O'Brien Williams Jr., was ...

San Francisco 49ers tight end George Kittle told reporters he had "no idea" why he received just two targets during a 35-10 ...

Rather than viewing this team as one of the class organizations of the NFC, we now need to ponder whether injuries, age, and ...

San Francisco 49ers All-Pro offensive lineman Trent Williams and his wife, Sondra, mourned the loss of their newborn child.

A Bills equipment cart awkwardly interrupted an NBC Sports Bay Area live segment after the 49ers' loss in Buffalo.

The Buffalo Bills hammered the San Francisco 49ers 35-10 in a snow-filled rout led by Josh Allen’s 4 TDs. Colin Cowherd ...

Buffalo Bills running back James Cook looked phenomenal in his team's Week 13 win over the San Francisco 49ers, and his ...

The NFL world was at a loss for words after San Francisco 49ers star Christian McCaffrey fell victim to another serious ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

Matthew Berry, Jay Croucher and Connor Rogers dive into the ramifications of star Christian McCaffrey's latest injury, ...

San Francisco 49ers player Trent Williams and his wife Sondra are mourning the passing of their newborn son, the couple ...