The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, and Thursday will be no

The San Francisco 49ers running back room is currently decimated by injuries. Superstar Christian McCaffrey (knee) sustained a PCL sprain in Week 13 and was placed on the injured reserve. No.2 option,

Three of last week’s top pickups — Isaac Guerendo (26.8 points), Adam Thielen (19.2) and Juwan Johnson (15) — won matchups in Week 14. Let’s try to hit on all four must-adds for Week 15, which omit the previously mentioned Thielen or the obvious Zach Charbonnet, who are priorities.

The 49ers host the Rams on Thursday Night Football. They’ve been losing running backs left and right, and now we’re awaiting final word on Isaac Guerendo’s game status.

While the door remains open for Isaac Guerendo to play on Thursday night, fantasy managers might want to keep an eye on Patrick Taylor.

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the remainder of the regular season. Well, Guerendo suffered an injury of his own last week and is in danger of missing a Thursday night matchup with the Rams.

Fantasy football analyst Scott Pianowski highlights the best (and worst) playoff schedules for receivers around the league. Knowledge is power! Neuroscientist and analyst Renee Miller arrives with advice to avoid our cognitive biases while making lineup decisions in the fantasy football playoffs.

Marcas Grant spotlights 10 sleepers to consider for your Week 14 fantasy football lineup, including the 49ers' new lead back, Isaac Guerendo, and three QBs with favorable matchups.