The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

The San Francisco 49ers will face the Los Angeles Rams in Week 15. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, especially regarding ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Well this isn't good. Rookie running back Isaac Guerendo is not participating in Tuesday's practice session with the San Francisco 49ers. Guerendo is nursing a ...

Christian McCaffrey and Jordan Mason both are on Injured Reserve, and now Isaac Guerendo has a foot/ankle sprain that he ...

San Francisco 49ers rookie running back Isaac Guerendo remains optimistic about his injury status after exiting Sunday's game ...