The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

The San Francisco 49ers host the Los Angeles Rams for Thursday Night Football but they may be without their standout rookie ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

San Francisco 49ers running back Isaac Guerendo has a foot sprain, per head coach Kyle Shanahan. 49ers HC Kyle Shanahan said ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

But Sunday was also the first game the Niners used Guerendo, their fourth-round pick in the 2024 draft and the fourth running ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

Status in question for Thursday ...

San Francisco 49ers rookie running back Isaac Guerendo remains optimistic about his injury status after exiting Sunday's game ...