The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

The San Francisco 49ers host the Los Angeles Rams for Thursday Night Football but they may be without their standout rookie ...

But Sunday was also the first game the Niners used Guerendo, their fourth-round pick in the 2024 draft and the fourth running ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

Christian McCaffrey and Jordan Mason both are on Injured Reserve, and now Isaac Guerendo has a foot/ankle sprain that he ...

San Francisco 49ers running back Isaac Guerendo suffered a foot injury in the team's game against the Chicago Bears.

San Francisco 49ers rookie running back Isaac Guerendo remains optimistic about his injury status after exiting Sunday's game ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.