San Francisco fumbled the ball three times and lost all three. Brock Purdy dropped back to pass 20 times for 86 net yards. Only one 49er had more than 20 receiving yards and the team’s lone touchdown came late in the third quarter after the Bills had already built a 28-3 lead.

The Buffalo Bills' first snow game of the season comes in an important showdown Sunday night against the San Francisco 49ers.

The San Francisco 49ers will have to deal with some real inclement weather for the first time this season when they visit the Buffalo Bills at Highmark Stadium. Just hours before kickoff, the field and seats were covered with snow due to a bevy of snow showers that

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second quarter against the Buffalo Bills.

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second quarter against the Bills.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night