San Francisco fumbled the ball three times and lost all three. Brock Purdy dropped back to pass 20 times for 86 net yards.

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

The 49ers (5-7) are alone in last place in the NFC West for the first time since the 2020 season ended. On the heels of this ...

The Bills are a Super Bowl contender and the 49ers somehow probably aren’t even a playoff team. That’s how Sunday night’s ...

A pair of Super Bowl hopefuls from each conference meet up on Sunday, Dec. 1 to close out the NFL schedule for the day with ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

The Buffalo Bills (9-2) will try to build on a six-game winning streak when they host the San Francisco 49ers (5-6) on Sunday ...

Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian ...

Buffalo (9-2) brings a six-game winning streak into a matchup with San Francisco (5-6) on Sunday, December 1, 2024 at ...