As a result, this protein can bind to HIF1β and facilitate gene transcription of many HIF target genes (Figure 1; Schofield & Ratcliffe, 2004). Some organisms, like the roundworm C. elegans ...

Our immune cells are not just “defenders” against deadly viruses and pathogens but also a great balancer for tissue homeostasis. For neurological disorders, understanding the neuro-immune axis could ...

The cells died in the most dangerous versions. The researchers discovered that the defective VHL gene elevated the activity of the HIF gene. While an excess of HIF protein can result in tumors ...

“Expression of one HIF-regulated vasoactive gene, ANGPTL4, cooperates with VEGF to promote the development of choroidal neovascularization and predicts the poor response to anti-VEGF therapy in ...