With its 35-10 loss at Buffalo on Sunday night, the 49ers have now dropped three straight to sink to 5-7 on the season. The blowout loss also marked the first time since 2015 and just the fourth time in franchise history that San Francisco has lost back-to-back games by 25 points or more.

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and San Francisco 49ers.

Patrick Everson breaks down the football weekend that was, including how the 49ers' struggles impacted the books, and some mixed reactions after UM stunned Ohio State.

Here's where the 49ers sit in the 2025 NFL Draft order after San Francisco's 35-10 blowout loss to the Buffalo Bills on Sunday at Highmark Stadium.

A picturesque setting of snow was the perfect backdrop for a Buffalo Bills team that has now won its fifth straight AFC East title.

Happy Holidays, football fans! The Bills kicked off the holiday season with a fun win over the 49ers in the snow on Sunday night.

The 2024 NFL Week 13 games end with Sunday Night Football as the Buffalo Bills host the San Francisco 49ers. NFL TV schedule, time and how to watch.

San Francisco 49ers running back Jordan Mason is going on injured reserve, head coach Kyle Shanahan announced.

The San Francisco 49ers running back injured the PCL in his knee, an MRI confirmed Monday. San Francisco plans to place McCaffrey on injured reserve. He is expected to miss six weeks. Head coach Kyle Shanahan announced the news during his Monday press conference.

The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their blowout Sunday night loss to Buffalo early after a non-contact injury that didn't look good.