Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

The current foci of diabetic neuropathy research are oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway. Figure 1 provides an overview of how ...

Companies such as Econic, Covestro, and Aramco Performance Materials (with intellectual property acquired from Novomer) have developed novel catalysts to facilitate CO 2-based polyol manufacturing.