San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...

San Francisco 49ers wide receiver Jauan Jennings rewards the 49ers' fourth-down call with a 26-yard catch and run.

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

RB Christian McCaffrey, playing in just his fourth game since returning from an Achilles injury, left Sunday night's game at ...

Christian McCaffrey will not return to Sunday's matchup against the Bills. McCaffrey has been downgraded to out with the knee ...

The Bills are just having fun in the snow in Orchard Park, with one of the more unique touchdowns you'll ever see giving the ...

It's a snow game in Orchard Park, and the Bills have had a clear advantage playing in the elements, taking a 21-3 lead into ...

San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after ...

McCaffrey slid down untouched in the backfield after taking a toss, then immediately went to the 49ers' medical tent and ...

A lot of things had to go right for the 49ers to hang around and give themselves a chance to pull off the upset against ...

While the 49ers welcome Brock Purdy back to the starting lineup at snow-covered Highmark Stadium, his immediate backup will ...

The San Francisco 49ers entered Sunday night's matchup against the Buffalo Bills at Highmark Stadium without several key ...