Heavy, lake-effect snow will fall on Buffalo this weekend as the 49ers arrive to face the Bills on Sunday night in the suburb ...

The San Francisco 49ers are set to visit Highmark Stadium this weekend for a critical Week 13 showdown against the Buffalo ...

San Francisco 49ers quarterback Brock Purdy appears to be making strides in his recovery from a shoulder injury. During the ...

The San Francisco 49ers announced the signing of offensive lineman Sebastian Gutierrez to the practice squad. To make room on ...

Let's start by acknowledging that this scenario is highly unlikely to unfold. While Brock Purdy's status for Sunday's playoff ...

Just as his predecessor, Steve Wilks, came under intense scrutiny a year ago, Nick Sorensen's first season as 49ers defensive ...

The San Francisco 49ers have signed defensive end Jonathan Garvin to the practice squad as they gear up for their Week 12 ...

Kyle Shanahan takes a pragmatic approach to handling online criticism—he ignores it. The San Francisco 49ers head coach ...

The Bills will not have one of their key offensive players for Sunday's game against the 49ers, though they could get one of ...

Brandon Allen will take the reins for the San Francisco 49ers on Sunday against the Green Bay Packers, marking his first NFL ...

There is no need to even discuss the 49ers' playoff possibilities until they get back to the .500 mark. That is, if they get ...

Here's everything you need to know for remaining Week 13 NFL games. Which teams will win, who are the X factors, and which ...