With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

The San Francisco 49ers will face the Los Angeles Rams in Week 15. Here’s the latest fantasy football news and advice to help you with your lineups this week and moving forward, especially regarding ...

The San Francisco 49ers running back room is currently decimated by injuries. Superstar Christian McCaffrey (knee) sustained ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

Status in question for Thursday ...

Kyle Shanahan shared his team's pre-practice injury report at a Tuesday press conference and it was the same as Monday's ...

Isaac Guerendo may still be available for Thursday night’s game against the Rams. San Francisco head coach Kyle Shanahan said ...

San Francisco 49ers running back Isaac Guerendo was nominated for the Pepsi Zero Sugar Rookie of the Week Award for Week 14 ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

The rookie running back showed off on an impressive drive that included a long catch and TD run against the Bears.