But Sunday was also the first game the Niners used Guerendo, their fourth-round pick in the 2024 draft and the fourth running ...

The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers host the Los Angeles Rams for Thursday Night Football but they may be without their standout rookie ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

Isaac Guerendo's status for Thursday's game is "up in the air" after suffering a foot sprain in a win vs. the Bears.

The San Francisco 49ers defeated the Chicago Bears 38-13 last weekend at Levi’s Stadium, putting them back in the winning column for the first time since they beat the Tampa Bay Buccaneers in Week 10.

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The San Francisco 49ers are reportedly expected to lean on rookie running back Isaac Guerendo for the remainder of the 2024 ...