Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Since returning from an Achilles tendinitis issue, Christian McCaffrey has dominated the San Francisco 49ers' backfield, ...

McCaffrey posted a statement on Instagram on Wednesday.

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

The 49ers' NFC matchup with the Chicago Bears on Sunday will be Isaac Guerendo’s chance to shine. The rookie running back has ...

After being placed on injured reserve following a PCL injury suffered in last Sunday's defeat to the Buffalo Bills, McCaffrey ...

San Francisco 49ers star Christian McCaffrey recently took to social media to send fans and supporters a message about his ...

The 49ers superstar made the statement in a lengthy caption on his Instagram fee after the team put him on injured reserve ...

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Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

In 40 other games at Wisconsin and Louisville, Guerendo played in a shared backfield –something he’s done with the 49ers this ...