Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFC West. Here are their grades for this per ...

The Buffalo Bills clinched another AFC East title with a dominant 35-10 win over the San Francisco 49ers; Josh Allen had ...

Somehow Week 13 was worse than for the San Francisco 49ers than Week 12. The 49ers fell behind 21-3 at halftime and had a ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian McCaffery and Deebo Samuel?

Christian McCaffrey was having a resurgent game against the Buffalo Bills. He finally looked like the player who was supposed ...

San Francisco 49ers running back Christian McCaffrey's season might be over after he suffered a PCL injury on "Sunday Night ...

San Francisco 49ers running back Christian McCaffrey suffered another injury in just his fourth game of the season. During ...

The San Francisco 49ers are reeling. They've lost two straight games to fall to 5-6 and under .500 for the fourth time this ...