Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFC West. Here are their grades for this per ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian ...

The Buffalo Bills clinched another AFC East title with a dominant 35-10 win over the San Francisco 49ers; Josh Allen had ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Podcast; ...

Christian McCaffrey was having a resurgent game against the Buffalo Bills. He finally looked like the player who was supposed ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

Analyzing Sunday’s San Francisco 49ers at Buffalo Bills odds and lines, with expert NFL picks and predictions.

The 49ers had three fumbles in Sunday night's contest, all three of which were recovered by the Bills. San Francisco's ...