19-10 in Chicago in 2022 and the last game in San Francisco, 14-9 in 2018. .@ProFootballTalk believes it would be wise for ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

Isaac Guerendo didn’t start in college until his final game.. He starts at running back for the 49ers Sunday against Chicago.

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

The San Francisco 49ers are a gigantic mess. Nothing looks right on offense. Injuries have decimated both sides of the ball.

The San Francisco 49ers have struggled to get Deebo Samuel going, and one NFL analyst thinks they may not be able to.

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Former Wisconsin Badgers running back Isaac Guerendo is in line to serve as the San Francisco 49ers starting running back for ...

Williams’ wife, Sondra, announced on Instagram on Sunday, Dec. 1 that their son Trenton O'Brien Williams Jr. was stillborn on ...

San Francisco 49ers' Trent Williams' wife Sondra has announced the death of their baby son at 35 weeks after losing his twin ...

Star pass-catcher George Kittle and the San Francisco 49ers play the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...