The 49ers had three fumbles in Sunday night's contest, all three of which were recovered by the Bills. San Francisco's ...

San Francisco 49ers quarterback Brock Purdy is active for the team's Week 13 matchup versus the Buffalo Bills.

San Francisco 49ers RB Christian McCaffrey powers through for a 19-yard run against the team's Week 13 matchup against the ...

Head coach Kyle Shanahan recapped the team's 35-10 loss to the Buffalo Bills, evaluated the 49ers performance on "Sunday ...

San Francisco 49ers RB Isaac Guerendo sped past the Buffalo Bills defense for a touchdown on "SNF" San Francisco 49ers RB ...

San Francisco 49ers RB Jordan Mason zipped through Bills defenders for a 27-yard run in the team's Week 13 matchup against ...

San Francisco 49ers WR Deebo Samuel Sr. has room to roam on a 60-yard kick return in the team's Week 13 matchup against the ...

The San Francisco 49ers promoted CB Nick McCloud to the active roster from the team's practice squad and activated LB Jalen ...

San Francisco 49ers TE George Kittle, LB Fred Warner and QB Brock Purdy outlined the team's performance on "SNF" against the Buffalo Bills.

The San Francisco 49ers released their latest injury updates headed into the team's Week 13 matchup vs. the Buffalo Bills.

The San Francisco 49ers announced they have signed OL Sebastian Gutierrez to the team’s practice squad and released OL ...

El corredor de los San Francisco 49ers, Isaac Guerendo, anota su segundo touchdown de la temporada tras un buen acarreo de 15 ...