San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after ...

The NFL is just about as unpredictable as the Buffalo weather at this time of the year, so the 49ers will take their ...

The 49ers won't have their best pass rusher when they face the Bills on Sunday. Nick Bosa will miss his second game in a row with an oblique injury ...

The 49ers don't know when their their Hall of Fame left tackle's ankle will heal. The team listed Trent Williams as out for the second game in a row ...

After missing Week 12 with a shoulder injury, 49ers quarterback Brock Purdy is ready to get back on to the field. The ...

The San Francisco 49ers announced Friday that they have waived wide receiver Ronnie Bell ahead of their Sunday night game ...

The San Francisco 49ers announced Friday that they have waived wide receiver Ronnie Bell ahead of their Sunday night game ...

San Francisco 49ers head coach Kyle Shanahan spoke with reporters after Friday's practice as the team prepares for its Week ...

The San Francisco 49ers are preparing for their Week 13 contest against the Buffalo Bills on Sunday at Highmark Stadium in ...

Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick ...

The 49ers are set to have quarterback Brock Purdy back in the lineup this weekend. Purdy missed last Sunday's loss to the ...

San Francisco 49ers quarterback Brock Purdy underwent an MRI early last week after sustaining a shoulder injury in the team's ...