One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

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The 49ers have been struggling for much of the season, but they had no shot in the snow on Sunday night in Western New ...

Watch highlights from the Week 13 matchup between the San Francisco 49ers and the Buffalo Bills during the 2024 ...

The 49ers' third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at ...

San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their ...

The San Francisco 49ers suffered another crushing defeat Sunday night, falling 35-10 to the Buffalo Bills. The loss marked ...

San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San Francisco 49ers put on a performance against the Buffalo Bills at Highmark ...

San Francisco 49ers wide receiver Jauan Jennings rewards the 49ers' fourth-down call with a 26-yard catch and run.

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San Francisco 49ers put on a performance against the Buffalo Bills at Highmark ...

A lot of things had to go right for the 49ers to hang around and give themselves a chance to pull off the upset against ...