Nevertheless, this study shows that targeting fungal histone acetylation using nicotinamide — which is well tolerated in humans — or future fungal sirtuin inhibitors is a novel strategy to ...

Furthermore, the researchers discovered that the sites where CREB interacted with DNA to promote gene expression require prior acetylation mediated by CBP. "These findings not only elucidate the ...

which paralleled acetylation of K9 and K14, while transcriptionally inactive chromatin was associated with K9 methylation. While this study supports the existence of gene regulation by a histone ...