There are bad bye weeks, and then there are season-ruining bye weeks. This could be the latter for many teams needing a ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

It should’ve been a night to remember for Mia DeCamilla, a young 49ers fan and cancer survivor who was attending her first ...

The Buffalo Bills clinched their record fifth consecutive AFC East title after defeating the San Francisco 49ers on Sunday ...

Sondra Williams, the wife of San Francisco 49ers left tackle Trent Williams, announced Monday that the couple had a son, ...

Lake-effect snow continued to fall on parts of western New York that were already blanketed with a foot or more over the past ...

Bills quarterback Josh Allen and head coach Sean McDermott celebrated by making snow angels after Buffalo clinched its fifth ...

Parts of the Great Lakes region saw new snow Monday and faced the prospect of even more this week after U.S.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday night, winning 35-10 in Highmark Stadium in Orchard Park, N.Y.

More than 4 million people across five states were under winter storm alerts on Sunday as heavy lake-effect snow continued to ...