The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the remainder of the regular season. Well, Guerendo suffered an injury of his own last ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

Three of last week’s top pickups — Isaac Guerendo (26.8 points), Adam Thielen (19.2) and Juwan Johnson (15) — won matchups in ...

Welcome to Week 15 of the NFL season, a week that is synonymous with the start of Fantasy football postseasons. Fortunately for you, we've got a rundown of every team's injury report so you know who ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

Here's the latest injury news on Derek Carr, Drew Lock and Isaac Guerendo and entering Week 15 of the NFL season.

San Francisco 49ers running back Isaac Guerendo was nominated for the Pepsi Zero Sugar Rookie of the Week Award for Week 14 ...

San Francisco 49ers rookie running back Isaac Guerendo remains optimistic about his injury status after exiting Sunday's game ...