The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the remainder of the regular season. Well, Guerendo suffered an injury of his own last ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

Welcome to Week 15 of the NFL season, a week that is synonymous with the start of Fantasy football postseasons. Fortunately for you, we've got a rundown of every team's injury report so you know who ...

Three of last week’s top pickups — Isaac Guerendo (26.8 points), Adam Thielen (19.2) and Juwan Johnson (15) — won matchups in ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

Kyle Shanahan shared his team's pre-practice injury report at a Tuesday press conference and it was the same as Monday's ...

Here's the latest injury news on Derek Carr, Drew Lock and Isaac Guerendo and entering Week 15 of the NFL season.

San Francisco 49ers running back Isaac Guerendo was nominated for the Pepsi Zero Sugar Rookie of the Week Award for Week 14 ...